A critical study of the Course in General Linguistics is here expanded to include Derrida's influential interpretation of this canonical text. It develops a critique of the philosopher's own critical reading of Saussure's linguistics, and it reveals a profound rapprochement between their respective views. The chapter re-examines relevant sections of the Course, approaching them through the lens of their deconstructive reading by Derrida in Of Grammatology (2016) and Glas (class="CitationRef">1986), and considering them in conjunction with relevant sources from Saussure's Nachlass. The goal is not simply to dismiss Derrida's insightful reading of Saussure. Instead, it turns out that general linguistics and deconstruction are closer than usually thought, and they can be productively combined in contemporary studies of cultural signification. For both Derrida and Saussure, cultural signification is mediated by the plexus of differences within the language system, and it is shaped by the so-called extralinguistic world.