Currently, the community of scientists seem to become more and more pragmatically-oriented. I have heard questions from psychiatrists and psychotherapists about a practical implications fo my theory and models. This chapter illustrates the application of the information model to integration the wide variety, clinically meaningful findings made within neurobiology, psychodynamic, cognitive and behavioral approach to psychopathology. The multiaxial schema for the psychotherapeutic diagnosis based on information metabolism theory is presented and illustrated in the case study.