Chapter 12 is devoted to the relevance of sequential time, a parameter time measuring the temporal distance between facts with a clock. But the apparently simple question of how facts are generated already leads to severe challenges that to date have not been uncontroversially resolved. In any event, once there are facts, they can be causally ordered, and experiments can be causally described. Most issues related to determinism, causation, prediction and retrodiction in science are based on sequential time.