Every amputee with postamputation pain asks how to control it: Pain is his main problem. Among current practices for treating pain, there are groups of medicaments that appear sufficiently effective. Of course, we must consider individual response to drugs, psychological repercussions of long-lasting pain, as well as the time-consuming observations and interactions of patient and physician. Concerning acute or persistent pain, patient and physician must agree on how to fight it: This is a basic requirement.